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Cardiovascular Disease I
Title
Cardiovascular Disease I
Editor
iConcept Press
Price
USD$109.99
ISBN
978-1-922227-54-6
Clicks
38070

Chapter 9

Cardiovascular Disease I

The Roles of Thiamine in Myocardial Infarction: Possible Genetic and Cellular Signaling Mechanisms

by Khanh vinh quốc Lương and Lan Thi Hoàng Nguyễn

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Abstract

Thiamine is known to play an important role in cardiovascular disease (CVD). The relationship between thiamine and myocardial infarction (MI) has been reported in the literature, and it is known that thiamine deficiency is highly prevalent in patients with MI. The administration of thiamine can substantially reduce lesions due to myocardial ischemia. Genetic studies have provided an opportunity to determine which proteins link thiamine to MI pathology, including the renin-angiotensin system, advanced glycation end product, and poly (ADP-ribose) polymerase-1. Thiamine also exerts its effect on MI through cell-signaling molecules, such as matrix metalloproteinases, mitogen-activated protein kinases, reduced nicotinamide adenine dinucleotide phosphates, prostaglandins, reactive oxygen species, and nitric oxide synthases. In conclusion, thiamine plays an important role in MI and may be administered at high doses to MI patients. Therefore, further investigation of the role of thiamine in patients with MI is warranted.

Author Details

Khanh vinh quốc Lương
Vietnamese American Medical Research Foundation, Westminster, California, United States, USA
Lan Thi Hoàng Nguyễn
Vietnamese American Medical Research Foundation, Westminster, California, United States, USA

Citation

Khanh vinh quốc Lương and Lan Thi Hoàng Nguyễn. The Roles of Thiamine in Myocardial Infarction: Possible Genetic and Cellular Signaling Mechanisms. In Cardiovascular Disease I. ISBN:978-1-922227-54-6. iConcept Press. 2014.

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