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Coronary Artery Disease: Research and Practice
Title
Coronary Artery Disease: Research and Practice
Editor
iConcept Press
Price
USD$39.00
ISBN
978-1-922227-98-0
Clicks
7401

Chapter 5

Coronary Artery Disease: Research and Practice

Vagus Nerve Stimulation: A Promising Cardioprotective Strategy against Ischemia-Reperfusion Injury

by Krekwit Shinlapawittayatorn, Siriporn Chattipakorn and Nipon Chattipakorn

Viewed: 1968

Abstract

Despite major advances in treatment of cardiovascular disease, myocardial infarction (MI) remains a common cause of heart damage throughout the world. Although restoration of blood flow to ischemic tissues is essential to prevent irreversible tissue damage and cell death, abrupt reperfusion can trigger a devastating cascade of rapidly-evolving, biological events ending with the activation of intracellular pathways that accelerate cell death. This phenomenon, so-called myocardial ischemia-reperfusion (I/R) injury, can paradoxically reduce the beneficial effects of myocardial reperfusion. Therefore, a novel therapeutic modality used as an adjunct to percutaneous coronary intervention to attenuate reperfusion injury could potentially improve the long-term outcome of MI patients. Moreover, it has been shown that cardiac autonomic imbalance is associated with increased mortality in MI patients. Over the past several years, enhancing parasympathetic activation of the autonomic nervous system by delivering electrical stimulation to the cervical vagus nerve, a procedure known as vagus nerve stimulation (VNS), has emerged as a promising therapy for various conditions, including brain and heart diseases. In this chapter, we mainly focus on the results of recent experimental animal studies that provide support for the possible use of VNS as a therapy for cardioprotection from I/R injury. In addition to exploring the effects of VNS on the infarct size, left ventricular function, hemodynamic parameters and arrhythmic events, this chapter will also address key modifiers that importantly contribute to vagal-mediated cardioprotective effects during myocardial I/R injury.

Author Details

Krekwit Shinlapawittayatorn
Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Thailand; Cardiac Electrophysiology unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Thailand
Siriporn Chattipakorn
Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Thailand; Department of Oral Biology and Diagnostic Science, Faculty of Dentistry, Chiang Mai University, Thailand
Nipon Chattipakorn
Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Thailand; Cardiac Electrophysiology unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Thailand

Citation

Krekwit Shinlapawittayatorn, Siriporn Chattipakorn and Nipon Chattipakorn. Vagus Nerve Stimulation: A Promising Cardioprotective Strategy against Ischemia-Reperfusion Injury. In Coronary Artery Disease: Research and Practice. ISBN:978-1-922227-98-0. iConcept Press. 2016.

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