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Oncology: Theory & Practice
Title
Oncology: Theory & Practice
Editor
iConcept Press
Price
USD$109.99
ISBN
978-1-922227-80-5
Clicks
26764

Chapter 4

Oncology: Theory & Practice

Urokinase-Type Plasminogen Activator System in Breast Cancer

by Ahmed H. Mekkawy, Krishna Pillai and David L. Morris

Viewed: 1861

Abstract

Urokinase-type plasminogen activator (uPA) system has broad physiological and patho-physiological functions including cancer progression and metastasis. Pre-clinical studies showed that uPA system modulates remodeling of the surrounding tissues as well as cleavage of basement membranes (BM) and extracellular matrix (ECM) components in addition to activation of latent growth factors. Moreover, uPA system activates several signaling pathways such as those contributing to cell proliferation, migration, invasion metastasis and angiogenesis. Distorted expression, secretion and functions of members of uPA system have been observed in a diverse group of human malignancies, including breast cancer. Correlation of these observations to clinical outcome has been well investigated in breast cancer patients. For instance, up-regulation of uPA and PAI-1 has been linked to poor prognosis in breast cancer patients. Moreover, targeting of uPA system expression or molecules is currently being studied as a prospective therapeutic strategy for cancer treatment.

Author Details

Ahmed H. Mekkawy
Department of Surgery, St George Hospital, University of New South Wales, Australia
Krishna Pillai
Department of Surgery, St George Hospital, University of New South Wales, Australia
David L. Morris
Department of Surgery, St George Hospital, University of New South Wales, Australia

Citation

Ahmed H. Mekkawy, Krishna Pillai and David L. Morris. Urokinase-Type Plasminogen Activator System in Breast Cancer. In Oncology: Theory & Practice. ISBN:978-1-922227-80-5. iConcept Press. 2014.

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