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Oncology: Theory & Practice
Title
Oncology: Theory & Practice
Editor
iConcept Press
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USD$109.99
ISBN
978-1-922227-80-5
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26766

Chapter 7

Oncology: Theory & Practice

Diagnosis of Primary Gastrointestinal Lymphomas and Mimics

by Mingyi Chen, Thomas J. Semrad and Jun Wang

Viewed: 3505

Abstract

Primary gastrointestinal (GI) lymphomas are predominantly non-Hodgkin lymphomas which comprise a heterogeneous group of distinctive clinicopathologic entities of B- or T-cell type, accounting for 10-15% of all non-Hodgkin lymphoma; whereas, primary gastrointestinal Hodgkin lymphoma is extremely rare. Primary lymphomas of the GI tract are important since their evaluation, diagnosis, management and prognosis are distinct from that of other cancers of the GI tract. The stomach is the most common site of involvement by primary gastrointestinal lymphomas, followed by the small intestine (except in the Middle East, where small intestinal tumors are the most common), ileum, cecum, colon, and rectum, while lymphomas of the esophageal primary are rare. The gastrointestinal tract is the most common site for involvement by extranodal lymphomas, with about 30-40% of such neoplasms presenting as GI primaries. While virtually any type of lymphoma may involve the GI tract, certain lymphoma types and clinical settings are associated with the highest rates of gastrointestinal involvement, and these will be the focus of this chapter. Diffuse large B-cell lymphoma is the most common type of primary GI lymphoma in nearly all sites of the GI tract. However, other types of lymphoma, particularly, the low grade lymphomas of mucosa-associated lymphoid tissue (MALT) type, have provoked the most interest in recent years. Other more unusual entities, such as double-hit lymphomas, enteropathy (celiac disease)-associated T-cell lymphoma (EATL), and hepatosplenic T-cell lymphoma, are also crucial for diagnosis of such lymphomas arising in the gastrointestinal tract. Since the GI tract is the predominant site of extranodal lymphoma involvement, benign conditions such as reactive follicular hyperplasia, NK-enteropathy, inflammatory pseudotumor and IgG4-related disease can represent diagnostically confusing and challenging mimics of lymphoproliferative malignancy.

Author Details

Mingyi Chen
Department of Pathology and Laboratory Medicine, University of California at Davis Medical Center, Sacramento, CA, USA
Thomas J. Semrad
Department of Internal Medicine, Division of Hematology and Oncology, University of California at Davis Medical Center, Sacramento, CA, USA
Jun Wang
Department of Pathology and Laboratory Medicine, Loma Linda University Medical Center, Loma Linda, CA, USA

Citation

Mingyi Chen, Thomas J. Semrad and Jun Wang. Diagnosis of Primary Gastrointestinal Lymphomas and Mimics. In Oncology: Theory & Practice. ISBN:978-1-922227-80-5. iConcept Press. 2014.

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