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Oncology: Theory & Practice
Title
Oncology: Theory & Practice
Editor
iConcept Press
Price
USD$109.99
ISBN
978-1-922227-80-5
Clicks
26773

Chapter 9

Oncology: Theory & Practice

Road to Cancer via Cohesin Deregulation

by Nenggang Zhang and Debananda Pati

Viewed: 1921

Abstract

Cohesin, an evolutionarily conserved protein complex, plays a pivotal role in maintenance of genomic stability. Apart from its canonical role in sister chromatid cohesion and separation, cohesin and its associated proteins are also involved in gene transcription, DNA damage repair, DNA replication and recombination, apoptosis, as well as centrosome biogenesis. Considering many of these cellular processes are hot spots in neoplasm, it is not surprising that deregulation of cohesin has been increasingly evident in human cancers. In this chapter we will review the cellular processes that are regulated by cohesin and discuss the significance of cohesin deregulation as a driver of tumorigenesis.

Author Details

Nenggang Zhang
Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, USA
Debananda Pati
Texas Children's Cancer Center, Department of Pediatrics, Baylor College of Medicine, USA

Citation

Nenggang Zhang and Debananda Pati. Road to Cancer via Cohesin Deregulation. In Oncology: Theory & Practice. ISBN:978-1-922227-80-5. iConcept Press. 2014.

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