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Oncology: Theory & Practice
Oncology: Theory & Practice
iConcept Press

Chapter 5

Oncology: Theory & Practice

Current Involvement and Clinical Relevance of Non-coding RNA Dysregulated Expression in Neuroblastoma

by Duncan Ayers and John Carabott

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Neuroblastoma is a paediatric tumour arising from primordial neural tissue and accounts for 15% of all paediatric tumour incidences. It also is the most common extra-cranial solid tumour to present in paediatric patients, with a mortality rate of approximately 50% when clinical presentation occurs in patients above the age of one year. In common with all other cancer conditions, there exists a myriad of molecular and genetic influences in driving the tumourigenesis and tumour aggressivity at the clinical level. The evidence for the critical clinical repercussions stemming from the dysregulated expression of novel molecular classes such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) is evermore present within a large spectrum of human disease conditions, including cancer. This chapter will serve to illustrate and summarise the majority of non-coding RNA research in the field of neuroblastoma, with particular focus on miRNAs and/or lncRNAs which have established themselves to be diagnostic and prognostic biomarkers for neuroblastoma at the clinical level.

Author Details

Duncan Ayers
Department of Pathology, Faculty of Medicine & Surgery / Faculty of Medical and Human Sciences, University of Malta / The University of Manchester, UK
John Carabott
Faculty of Health Sciences, University of Malta, Malta


Duncan Ayers and John Carabott. Current Involvement and Clinical Relevance of Non-coding RNA Dysregulated Expression in Neuroblastoma. In Oncology: Theory & Practice. ISBN:978-1-922227-80-5. iConcept Press. 2014.