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Oncology: Theory & Practice
Title
Oncology: Theory & Practice
Editor
iConcept Press
Price
USD$109.99
ISBN
978-1-922227-80-5
Clicks
26768

Chapter 6

Oncology: Theory & Practice

The Clinical Significance and Biology of Thymidine Kinase 1

by Melissa M. Alegre, Richard A. Robison and Kim L. O'Neill

Viewed: 1876

Abstract

Cancer is a complex disease in which there is still a great need for clinically relevant biomarkers. Thymidine Kinase 1 (TK1) is one cancer biomarker which has value both in early detection and monitoring treatment responsiveness. TK1 is primarily responsible for maintaining thymidine nucleotide pools by converting dT to dTMP. In malignancy, TK1 plays a crucial role in DNA damage, a potential mechanism of resistance. Additionally, the structure of TK1 is essential to its function and regulation in malignancy. A thorough understanding of these aspects helps to explain the challenges associated with TK1’s detection and its transition into the clinic. In malignancy, TK1 is elevated in both the serum and tumor tissue in the very early stages of tumor development. This is true for a wide variety of malignancies including both haematological and solid tumors. Several studies have reported that elevated serum TK1 levels in healthy individuals are associated with a significantly higher risk for pre-malignant progression, including the risk for developing new malignancies. Typically its elevation is correlated to stage and grade of a tumor. High levels of TK1 are indicative of a worse prognosis and greater risk of recurrence. In fact, numerous studies have revealed that serum-TK1 levels begin to elevated months before a patient relapses. In comparison studies with other proliferation markers and other serum biomarkers, TK1 appears to be more accurate and sensitive. Additionally, TK1 has therapeutic potential and has begun to be used as an imaging tool for positron emission tomography (PET). As TK1 is propelled into clinical view, it becomes more essential to understand the basic biology and clinical advances associated with this promising biomarker. This review seeks to highlight these important advances to help propagate a wide-spread understanding of TK1.

Author Details

Melissa M. Alegre
Microbiology and Molecular Biology, Brigham Young University, USA
Richard A. Robison
Microbiology and Molecular Biology, Brigham Young University, USA
Kim L. O'Neill
Microbiology and Molecular Biology, Brigham Young University, USA

Citation

Melissa M. Alegre, Richard A. Robison and Kim L. O'Neill. The Clinical Significance and Biology of Thymidine Kinase 1. In Oncology: Theory & Practice. ISBN:978-1-922227-80-5. iConcept Press. 2014.

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