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Protein Purification: Principles and Trends
Title
Protein Purification: Principles and Trends
Editor
iConcept Press
Price
USD$89.00
ISBN
978-1-922227-40-9
Clicks
20061

Chapter 7

Protein Purification: Principles and Trends

Cholesterol and Liver Inflammation: from Mice to Human

by Sofie M. A. Walenbergh, Tim Hendrikx and Ronit Shiri-Sverdlov

Viewed: 1580

Abstract

Obesity goes hand in hand with an increased risk for several inflammatory diseases, such as atherosclerosis and non-alcoholic steatohepatitis (NASH). A consistent risk factor for the development of inflammation in the context of obesity is dietary cholesterol. Therefore, in this chapter, we summarize mouse and human studies that provide mechanisms by which cholesterol could affect inflammation. Apart from the direct effects, its intracellular localization as well as the contribution of different types of cholesterol to the inflammatory response is highlighted. Additionally, when oxidized, cholesterol is more likely to instigate inflammation. This book chapter is aimed at offering an updated overview from basic research work concerning cholesterol and inflammation to potential therapeutic targets.

Author Details

Sofie M. A. Walenbergh
Department of Molecular Genetics, Faculty of Health, Medicine and Life Sciences, Maastricht University, Netherlands
Tim Hendrikx
Department of Molecular Genetics, Faculty of Health, Medicine and Life Sciences, Maastricht University, Netherlands
Ronit Shiri-Sverdlov
Department of Molecular Genetics, Faculty of Health, Medicine and Life Sciences, Maastricht University, Netherlands

Citation

Sofie M. A. Walenbergh, Tim Hendrikx and Ronit Shiri-Sverdlov. Cholesterol and Liver Inflammation: from Mice to Human. In Protein Purification: Principles and Trends. ISBN:978-1-922227-40-9. iConcept Press. 2016.

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