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Research on Immunology
Title
Research on Immunology
Editor
iConcept Press
Price
USD$39.00
ISBN
978-1-922227-91-1
Clicks
10832

Chapter 4

Research on Immunology

Understanding the Roles of the Immune System in Cow’s Milk Allergy

by Juandy Jo, Johan Garssen, Leon M.J. Knippels and Elena Sandalova

Viewed: 932

Abstract

Food allergy is an aberrant immune-mediated reaction against harmless food substances, such as cow’s milk proteins. Due to its very early introduction, cow’s milk allergy is one of the earliest and most common food allergies. For this reason cow’s milk allergy can be recognized as one of the first indications of an aberrant inflammatory response in early life. Classically, cow’s milk allergy, as is true for most other allergies as well, is primarily associated with the elevation of allergen-specific immunoglobulin E levels. In addition, immunoglobulin-free light chains is postulated to mediate pathogenesis of hypersensitivity reactions as well. In contrast, immunoglobulin G4 is suggested to confer protection against inflammatory reactions including allergy, due to its anti-inflammatory activity. There is growing evidence also indicating that cellular components of both innate and adaptive immunity play significant roles during the pathogenesis of cow’s milk allergy. This is true for the initiation of the allergic phenotype (stimulation and skewing towards sensitization), development as well as outgrowth of the allergic disease. This review discusses findings pertaining to roles of both humoral and cellular immunity in allergic inflammation as well as tolerance induction against cow’s milk proteins. Therapeutic strategies to induce specific immune tolerance are also discussed. In addition, a possible interaction between immune mechanisms underlying cow’s milk allergy and other types of inflammation (infections and non-communicable diseases) is discussed.

Author Details

Juandy Jo
Program of Immunology, Nutricia Research, Singapore
Johan Garssen
Department of Immunology, Nutricia Research, Utrecht, Netherlands; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands
Leon M.J. Knippels
Department of Immunology, Nutricia Research, Utrecht, Netherlands; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands
Elena Sandalova
Program of Immunology, Nutricia Research, Singapore; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands

Citation

Juandy Jo, Johan Garssen, Leon M.J. Knippels and Elena Sandalova. Understanding the Roles of the Immune System in Cow’s Milk Allergy. In Research on Immunology. ISBN:978-1-922227-91-1. iConcept Press. 2016.

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