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Research on Immunology
Title
Research on Immunology
Editor
iConcept Press
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USD$39.00
ISBN
978-1-922227-91-1
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11406

Chapter 5

Research on Immunology

Immune Mechanisms in Non-alcoholic Steatohepatitis (NASH)

by Akinobu Takaki, Nozomu Wada and Kazuhide Yamamoto

Viewed: 1970

Abstract

Non-alcoholic steatohepatitis (NASH) is a severe form of non-alcoholic fatty liver disease (NAFLD), in which most patients exhibit non-progressive, non-alcoholic fatty liver (NAFL) attributable to simple steatosis. Multiple hits, including genetic differences, fat accumulation, insulin resistance, immune mechanisms and intestinal microbiota changes, account for the progression of NASH. NAFLD is strong-ly associated with obesity, which induces adipokine secretion, endoplasmic reticulum (ER) and oxidative stress at the cellular level, which in turn induces hepatic steatosis, inflammation and fibrosis. Oxidative stress is considered to be a key contributor in the progression from NAFL to NASH and antioxidant treatment is the standard care for NASH. Although several clinical trials have shown that antioxidative therapy with vitamin E can effectively control hepatitis pathology in the short term, the long-term ef-fects remain obscure and have often proved to be ineffective in many other diseases. Several long-term antioxidant protocols have failed to reduce mortality. New treatment modalities that incorporate current understanding of NAFLD molecular pathogenesis must be considered. Recent investigations suggests another treatment protocols such as immune regulator or probiotics. Macrophage infiltration is apparent in NAFL and NASH, while T-cell infiltration is apparent in NASH. The cytokine pattern is also divided by NAFL and NASH. Immune mechanisms should be involved and there must be possibilities for new immune-related treatment.

Author Details

Akinobu Takaki
Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
Nozomu Wada
Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan
Kazuhide Yamamoto
Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan

Citation

Akinobu Takaki, Nozomu Wada and Kazuhide Yamamoto. Immune Mechanisms in Non-alcoholic Steatohepatitis (NASH). In Research on Immunology. ISBN:978-1-922227-91-1. iConcept Press. 2016.

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