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Research on Immunology
Title
Research on Immunology
Editor
iConcept Press
Price
USD$39.00
ISBN
978-1-922227-91-1
Clicks
12033

Chapter 2

Research on Immunology

Immune Imbalance in Nasal Polyps of Caucasian Chronic Rhinosinusitis Patients

by Michael Könnecke, Robert Böscke, Anja Waldmann, Karl-Ludwig Bruchhage, Robert Linke, Ralph Pries and Barbara Wollenberg

Viewed: 1571

Abstract

Chronic rhinosinusitis with nasal polyps (CRSwNP) in Caucasians is a chronic Th2 inflammatory disease of the nasal and paranasal mucosa with a prevalence about 1-4% of the general population. The pathogenesis of CRSwNP remains unclear, especially the ongoing chronic inflammation. The recruitment of leukocytes to the site of inflammation in CRSwNP patients is poorly understood. In order to get a better understanding of the recruitment of leukocytes in CRSwNP patients, we analyzed mRNA and protein expression profiles of adhesion molecules in nasal polyp tissues using molecular, biochemical and immunohistological methods. In nasal polyps, E-selectin, CXCL4 and CXCL5 expression was significantly decreased and came along with an increased P-selectin expression. Interestingly, eosinophil and neutrophil counts differed significantly in nasal polyps, while balanced counts could be detected in inferior turbinates. Diffentent therapies could reestablish the immune balance between eosinophils and neutrophils in Caucasian nasal polyps and could represent promising strategies for the future.

Author Details

Michael Könnecke
Department of Otorhinolaryngology, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany
Robert Böscke
Department of Otorhinolaryngology, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany
Anja Waldmann
Department of Otorhinolaryngology, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany
Karl-Ludwig Bruchhage
Department of Otorhinolaryngology, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany
Robert Linke
Department of Otorhinolaryngology, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany
Ralph Pries
Department of Otorhinolaryngology, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany
Barbara Wollenberg
Department of Otorhinolaryngology, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany

Citation

Michael Könnecke, Robert Böscke, Anja Waldmann, Karl-Ludwig Bruchhage, Robert Linke, Ralph Pries and Barbara Wollenberg. Immune Imbalance in Nasal Polyps of Caucasian Chronic Rhinosinusitis Patients. In Research on Immunology. ISBN:978-1-922227-91-1. iConcept Press. 2016.

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