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Research on Immunology
Title
Research on Immunology
Editor
iConcept Press
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USD$39.00
ISBN
978-1-922227-91-1
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11407

Chapter 6

Research on Immunology

Cytokine Immunopathogenesis of Enterovirus 71 Infection

by Shih-Min Wang and Ching-Chuan Liu

Viewed: 1488

Abstract

Enterovirus 71 (EV71) is one of the most important causes of herpangina and hand-foot-and-mouth disease. EV71 infection It can also cause severe brings about the complications of the central nervous system (CNS). Brain stem encephalitis with pulmonary edema is the severest complication that can lead to death. EV71 replicates in leukocytes, endothelial cells and dendritic cells resulting in the production of immune and inflammatory mediators that shape innate and acquired immune responses and the complications of disease. Cytokines are crucial for fighting infection and establishing immunity, as a part of innate immunity, favor the development of antiviral and Th1 immune responses. Dysregulation of these cytokines can lead to excessive inflammation or increased pathology. It has been shown that downregulating inflammatory immune responses may improve outcome. Cytokines and chemokines play an important roles in the pathogenesis EV71 brain stem encephalitis. Both the CNS and the systemic inflammatory responses to infection play important principle, but distinctly different, roles in the pathogenesis of EV71 pulmonary edema. Administration of intravenous immunoglobulin and milrinone, a phosphodiesterase inhibitor, has been shown to modulate inflammation, to reduce sympathetic overactivity, and to improve survival in patients with EV71 autonomic nervous system dysregulation and pulmonary edema.

Author Details

Shih-Min Wang
Departments of Pediatrics and Emergency Medicine, National Cheng Kung University and Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan
Ching-Chuan Liu
Departments of Pediatrics and Emergency Medicine, National Cheng Kung University and Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan

Citation

Shih-Min Wang and Ching-Chuan Liu. Cytokine Immunopathogenesis of Enterovirus 71 Infection. In Research on Immunology. ISBN:978-1-922227-91-1. iConcept Press. 2016.

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