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Virology II: Advanced Issues
Title
Virology II: Advanced Issues
Editor
iConcept Press
Price
USD$128.00
ISBN
978-1-922227-45-4
Clicks
16887

Chapter 16

Virology II: Advanced Issues

HCV helicase as a therapeutic target

by Adil A. Shah, Summer Siddiqui and Syed H. Ali

Viewed: 2193

Abstract

Hepatitis C virus (HCV) is the causative agent of acute and chronic liver disease in humans, including chronic hepatitis, cirrhosis, and hepatocellular carcinoma. The current therapeutic tools against HPV infection include Interferon therapy in various forms along with ribavirin. However, not all the genotypes respond similarly to these therapies and most of the patients eventually become resistant to the treatment. Additionally, this treatment has a number of adverse effects and, especially for the patients in developing countries, its cost is unaffordable. Research on molecular dynamics of HCV proteins has led to the identification of novel therapeutic targets. The HCV-encoded non-structural protein, NS3, has recently emerged as a promising drug target for anti-viral therapy. Here we present a review on the advances made so far in search of novel drug targets against the HCV NS3 protein.

Author Details

Adil A. Shah
Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan, Pakistan
Summer Siddiqui
Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan, Pakistan
Syed H. Ali
Aga Khan University, Algeria

Citation

Adil A. Shah, Summer Siddiqui and Syed H. Ali. HCV helicase as a therapeutic target. In Virology II: Advanced Issues. ISBN:978-1-922227-45-4. iConcept Press. 2014.

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