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iConcept Journal of Computational and Mathematical Biology
Title
iConcept Journal of Computational and Mathematical Biology
Editor
Maurice Ling
ISSN
2219-1402
Publisher
iConcept Press

iConcept Journal of Computational and Mathematical Biology

Aerosol Bolus Inhalation in Subjects with Different Age – A Theoretical Approach

by Robert Sturm

Volume: 3 (2014); Issue: 7

Abstract

The behavior of aerosol boluses inhaled by subjects with different age (1 y – 20 y) was theoretically studied. Main parameters of pulmonary bolus transport were modeled by using (a) a stochastic lung architecture, (b) an algorithm assuming random particle trajectories, and (c) the mathematical concept of effective diffusivities. Adaptations of inhalative and morphometric factors to subject’s age were conducted by specific scaling functions. As demonstrated by the modeling results, both aerosol bolus dispersion and standard deviation increase with age according to a polynomial of degree 2. A contrary behavior may be attested for bolus mode-shift, showing a linear decrease from 1-y-old subjects to 20-y-old subjects. Bolus skewness and particle deposition from the bolus exhibit a linear increase with age, whereby in the first case regression calculation is characterized by noticeable uncertainties. Based on the theoretical results, it may be concluded that infants’ and children’s lungs react with lower sensitivity on inspired aerosol boluses than adults’ lungs. This has important consequences with regards to the use of bolus inhalation for therapeutical purposes.

Author Details

Robert Sturm
Department of Physics and Biophysics, Faculty of Natural Sciences, University of Salzburg, Austria

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