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iConcept Journal of Emerging Issues in Medical Diagnosis and Treatment
Title
iConcept Journal of Emerging Issues in Medical Diagnosis and Treatment
Editor
Eugenia Giannopoulou
ISSN
2309-3528
Publisher
iConcept Press

iConcept Journal of Emerging Issues in Medical Diagnosis and Treatment

Current Concept of Sarcopenia and its Neurogenic Model

by Ping Kwan

Volume: 3 (2014); Issue: 4
Status: Copy Editing and Typesetting

Abstract

Sarcopenia is a progressive muscle degeneration associated with aging. This muscle disorder affects mainly the aged individuals who are commonly manifesting an age-related structural and functional impairment of skeletal muscles. Together with dynapenia, sarcopenia results in a net lost of muscle mass, strength, contractile capacity and physical endurance which ultimately leads to an impairment of ambulation, mobility, energy intake, overall nutrient intake/status, independence, and breathing. Such a change in quality of life demands an imperative investigation into the mechanism, based on which an effective countermeasure can be developed. This chapter will provide an overview about the current concepts in sarcopenia research. Additionally, the multi-etiological character of this muscle disorder will be discussed along with its neurogenic model. This chapter will focus mainly on the action of motor unit and the impacts derived from the aging nervous system (from both the neurons and glia). It has been suggested that aging-associated dysfunction of muscle fiber reinnervation in the elderly could be one of the main causes of sarcopenia. The potential value of such target in respect to sarcopenia will be discussed.

Author Details

Ping Kwan
School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong

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