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iConcept Journal of Emerging Issues in Medical Diagnosis and Treatment
Title
iConcept Journal of Emerging Issues in Medical Diagnosis and Treatment
Editor
Eugenia Giannopoulou
ISSN
2309-3528
Publisher
iConcept Press

iConcept Journal of Emerging Issues in Medical Diagnosis and Treatment

Combination of Etoposide and Docosahexaenoic Acid via Targeting PI3K/MAPK Pathway May Be A New Therapeutic Strategy for Medulloblastoma

by Shuang Zhou, Fengfei Wang and Erxi Wu

Volume: 3 (2014); Issue: 3
Status: Copy Editing and Typesetting

Abstract

Medulloblastoma (MB) is the most common malignant brain tumor occurring in children. It is manifested in both metastatic and non-metastatic forms. There is no effective therapy currently available for the patients with metastatic MB, and the long-term survivors suffer from significant disabilities caused by the concomitant toxicities of current treatments. The new effective therapies are needed. In our recent studies conducted by Wang et al., 2011, we observed that omega-3 fatty acid, docosahexaenoic acid (DHA), sensitizes MB cells to etoposide-induced apoptosis at least in part through down regulation of PI3K/MAPK pathways. Intensive suppression in the gene expression levels of PI3K/MAPK signaling, including the key components Akt, PTEN, PIK3R1, PIK3CB, JUN, MAP2K1, and MAPK14, was revealed in the MB cells treated with the combination of DHA and etoposide, in comparison to the cells treated with etoposide. These results suggest that patients with MB may benefit from therapies combining DHA with etoposide and the development of a novel therapy targeting PI3K/MAPK signaling is a promising strategy to enhance the efficacy of current chemotherapies in MB. In this review, we will further summarize the latest view regarding MB, review the major signaling pathways involved in MB formation and progression, analyze the data obtained in our study of DHA and its combination with etoposide in MB cells, and discuss the pathways of cell growth and apoptosis that differentially influenced by DHA and and the combined DHA-etoposide treatments.

Author Details

Shuang Zhou
Department of Pharmaceutical Sciences, North Dakota State University, USA
Fengfei Wang
Department of Pharmaceutical Sciences, North Dakota State University, USA
Erxi Wu
Department of Pharmaceutical Sciences, North Dakota State University, USA

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