iConcept Press Logo
Email Password Remember me
Immunotherapeutic Approaches for Neurological Diseases: Natural Monoclonal Antibodies and Conventional Monoclonal Antibodies
Lecture Notes in Medical Diagnosis and Treatment

Immunotherapeutic Approaches for Neurological Diseases: Natural Monoclonal Antibodies and Conventional Monoclonal Antibodies

Immunotherapeutic Approaches for Neurological Diseases: Natural Monoclonal Antibodies and Conventional Monoclonal Antibodies

Editor:
ISBN: 978-1-922227-393
Pages: 86
Price: USD$29.00

Immunoglobulins with germline sequences occur in invertebrates and vertebrates and are named ‘natural antibodies’ (NAbs). They may target foreign antigens, self- or altered self-components and are part of the normal immunoglobulin repertoire. NAbs can act as systemic surveillance molecules, which tag damaged or stressed cells, invading pathogens and toxic protein aggregates for elimination by the immune system. Certain NAbs actively signal in different cell types with a broad range of responses from induction of apoptosis in cancer cells, stimulation of remyelination in glial cells and blocking disease propagation in neurodegenerative disorders. This lecture note emphasizes the different functions and characteristics of NAbs and their use as potential therapeutics in multiple sclerosis (MS) as an example for neuroinflammatory diseases. Within neurodegenerative diseases we will focus on Alzheimer’s disease as the best investigated disease for immunotherapeutic approaches. We will highlight the role of the blood brain barrier (BBB) as the major obstacle for antibody based therapies of CNS diseases and stress on some novel approaches to lower the hurdle.

Table of Contents

List of Figures

Figure 1
Figure 2

List of Tables

Table 1

Download

Downloading the content requires one of the following:

  • Institutional Perpetual Access

    Lecture notes can be licensed to institutions as perpetual access purchases. To recommend a purchase, please consult your institution's librarian or knowledge management professional. For more information, please click: Institutional Perpetual Access.
  • Personal Perpetual Access

    If your institution is not able to purchase perpetual access, you can purchase personal perpetual access for your own use. After purchasing, you can download all our lecture notes. For more information, please click: Personal Perpetual Access.
  • Pay-Per-View

    You can purchase this lecture note for USD$10.00. After purchasing, you can download this lecture note at any time you want for unlimited number of times.

    To purchase this lecture note:

    • If you have an account, please login below:
      Email
      Password
      Remember Me
    • If you do not have an account, please register: